Document Type : Original Article
Authors
1
Cairo university
2
Faculty of Biotechnology, October University for Modern Science and Arts (MSA), Giza, Egypt.
3
Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza, 12613, Egypt
4
Biochemistry department, Faculty of Agriculture, Cairo University, Giza, Egypt
5
Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza, 12613, Egypt.
Abstract
Plant secondary metabolites are bioactive compounds with antioxidant, antimicrobial, and antiviral effects, offering potential in preventing oxidative stress-related diseases like cancer, neurodegeneration, and chronic inflammation. The study investigated the chemical composition and biological activity of ethanol extracts from Cuminum cyminum (cumin) and Erythranthe moschata (musk monkeyflower), highlighting their therapeutic potential. The study analyzed the extracts for their content of phenols, flavonoids, condensed tannins, and ascorbic acid, using HPLC to identify specific phenolic compounds. The antioxidant capacity was evaluated through multiple assays, including DPPH, ABTS, KMnO₄, H₂O₂. Antibacterial activity was assessed by the agar well diffusion method, and antiviral activity was evaluated using the MTT assay on Vero E6 cells infected with human coronavirus 229E. Results showed that cumin extract contained higher levels of phenolics and flavonoids, contributing to its stronger antioxidant activity, whereas musk extract had elevated ascorbic acid content and demonstrated moderate antiviral effects. Both extracts exhibited antimicrobial properties, indicating their potential as sources of bioactive compounds for further investigation in the context of oxidative stress-related diseases. These findings highlight the therapeutic promise of plant-derived metabolites and support the need for further pharmacological investigation.
Keywords
Main Subjects
)
View on SCiNiTO